Open the config/livewire.php file and change this:

'middleware_group' => ['web'],

to this:

'middleware_group' => [
    InitializeTenancyByDomain::class, // or whatever tenancy middleware you use

Now you can use Livewire both in the central app and the tenant app.

Also make sure to enable universal routes.

And if you're using file uploads, read the Real-time facades page of the documentation. Livewire uses real-time facades in the uploading logic.